The receptionist said "Ah, Mr. Spider what can I-"
Mr. Spider said "Doctor Doctor! Is he in? I need to see him!"
The receptionist pushed a button and typed a few things... then responded "Yeah... Um... well he's in his lab room so... as long as you don't interfere with his studies."
Mr. Spider asked "Can you ask him to leave a window open?"
The receptionist typed something in and said "Doctor Doctor says "Sure... Fine feel free to swing in why don't you?"." and in Response Mr. Spider was out of the building and web swinging his way up the tower to Doctor Doctor's room, which had a window open wide enough for Mr. Spider to swing in and close. After all his room was on a floor high enough to bring in some considerable wind. On the opposite side of the room sat Doctor Doctor at some lab table. He was one of those heroes who didn't need to be concerned with a secret identity. In fact he was less of a "stopping evil" hero now as he was a "Finding cures to cancer" type of hero. Even his old enemies stopped going after him as his work ended up profiting them and society as a whole, and no one really wanted him to get out of his ass kicking retirement. He may not have had any real powers, but the man and his anti-aging serum had kept his hair nice and full in a chestnut brown and he was a strong human as he kept going to the Protector's gym.
Doctor Doctor asked "That you Mr. Spider? What brings you to my study?"
Mr. Spider asked "...Say are you really a doctor and have that confidentiality stuff?"
Doctor Doctor said "Yes, before becoming a super hero I did get my degree. With the work I did to my own brain not even a telepath can figure out who I've taken care of. What's the issue?"
"Well Doc, The latest super villain I've taken care of did something to me and I'm turning into a girl..."
Doctor Doctor said "Well I don't have any medicine to change someone's gender. Although if you want a check up I can always do that."
"Thank's doc, any chance you could make something to help?"
"First take off your suit." as such Mr. Spider took off everything besides his mask down to his boxers. "...and the boxers, if you are turning into a woman I need to see how your little buddy is doing." After a slight hesitation Mr. Spider also took off his boxers leaving him more or less nude besides the mask. Checking Mr. Spider's pulse, genitals, reflexes, etc. Doctor Doctor calmly said "Yeah, your penis and balls are shrinking and should be gone within half an hour... your muscle mass seems to be shrinking, but your reflexes should be retained and while I wouldn't suggest lifting a building your super strength should be good enough for your general crime fighting status."
"Any chance It'll wear off or you can find something to change me back?"
"No idea, It's too early to say what the power is doing to you exactly. Although from the way your voice is going you are going to be female. Maybe go easy and... Right you are one of those unknown super heroes who keep their identities away from their families. Got a cover story for them?"
"Already taken care of. Not sure how long I can convince them I'm not in any danger or anything, but-"
"Well we have vacancies here at The Protectors for a reason..." Doctor Doctor started thinking "How about I put you right in between Captain Spectacle and The Magical Girl Squad?"
"... I'm going to get some sleep... Have any hair dye?"
"What for Ms. Spider?"
"This mask gets stuffy, If i'm going to be female then my face isn't an issue but I'd rather not have my actual hair color be on display." Doctor Doctor went into his drawer and pulled out a bottle of some blue stuff.
Doctor Doctor explained "Technically this is a failed experiment and doesn't do anything but stain your hair blue... So it's close enough to hair dye. Get dressed up, get your key, and go to your room. It should have some one size fits all pajamas and clothes for a women so... We'll see how this goes, and come in tomorrow for an examination."
Mr. Spider did exactly that, and snuck into his temporary room at The Protectors. It wasn't that late, but not really feeling like doing much Mr. Spider quickly dyed all of his hair and then just took off all his suit and went to sleep in his boxers... his buddy now gone... When he woke up...