Vivian wasn't having a good day, not that he ever had much of those. First his name, while historically gender-neutral, had long before the great calamity come to be considered a feminine one. What had come over his father give him such a name? Coupled with this the fact he always had been very emotional, rather stupid and probably one of the less strong kid ever, and you understand why he was among the peoples chosen for hyper-feminization. A fact that really depressed him.
Unknown by everyone, a natural woman had successfully infiltrated the base and exchanged the mind-altering drugs given to ‘worthy’ boys and to (future) new-girls. Said natural woman was a rather masculine looking one who could easily pass for a man.
Another thing that nobody knew, because it was never tested, is that the drug given to the ‘worthy’ would have worked better on the ‘unworthy’, and vice-versa. The more stupid you were, the more intelligent the ‘worthiness’ drug would make you. (While the other one had the exact opposite effect.)
So while Vivian cried all the way to his injection capsule, during said injection and wile the first injection turned him into a new-woman, it changed with the second injection. Not immediately, of course, but as soon as he realized things weren't turning as they should. Instead of turning into some exaggeratedly feminine living sex-toy like her mother, she was becoming very strong, but somehow without loosing any of her newfound femininity. Rather than looking like an ugly bodybuilder, she looked like a woman of old practicing sport on a professional level. She had become what would have been called a ‘sexy (and sporty) tomboy’ by men from before the Great Calamity.
Another change she could feel was how much more intelligent she was. She didn't know it yet, but even the more intelligent men of her country (formerly a state from the United-States of America, before the Great Calamity made most countries of old collapse) seemed dumb compared to her. She didn't take long to foment an escape plan, then several backup plans just in case, and share it with her fellow new-girls. In fact, she was already thinking on how she could overthrow the current government. What she wasn't sure yet is if she should make it so men and women were equal, or replace the currently patriarchal society with a matriarchal one.
The overseer for their part didn't notice the rebellion that was brewing in the hyper-feminization room, far too preoccupied by the now dumber than dumb and very docile men in the hyper-masculinization room, so much that some of them were even too dumb to breath and died from asphyxiation, and others would gladly stop breathing if asked to do so.